This is the truck for contractors and others who need a versatile and capable cargo hauler. GMC equips the Sierra with range of engines from a 4.3L V-6 to a 6.2L V-8. A choice of 6.5' and 8' bed lengths is available on Regular and Extended Cab models with 2WD or 4WD drivetrains. Braking duties are handled by disc/drum (except Denali) layout. Optional alloy wheels in 17, 18, and 20-inch diameter are available; tire sizes range from P245/45R17 to P275/55R20. The Sierra 1500 is a good value for a full-size truck, and offers a surprisingly refined driving experience.

The Sierra 1500 series trucks see a number of powertrain revisions for 2010. Most 1500 models are powered by either a 4.8L V8 or 5.3L V8. Both engines can run on ethanol and feature variable valve timing and cylinder deactivation. The 6.0L V8 has been dropped.