| Model/Trim/Package | Engine | MPG | VjI | MSRP | ||
|---|---|---|---|---|---|---|
| RX 350 | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $49,725 |
| RX 350 | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $51,325 |
| RX 350 Premium | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $51,900 |
| RX 350 Premium | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $53,500 |
| RX 350 F Sport Design | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $54,230 |
| RX 350 Premium+ | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $55,390 |
| RX 350 F Sport Design | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $55,830 |
| RX 350 Premium+ | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $56,990 |
| RX 350 F Sport Handling | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $58,500 |
| RX 350 Luxury | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $60,445 |
| RX 350 Luxury | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $62,045 |
| RX 350h | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $52,025 |
| RX 350h Premium | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $54,200 |
| RX 350h F Sport Design | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $56,530 |
| RX 350h Premium+ | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $57,690 |
| RX 350h Luxury | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $62,045 |
| RX 450H+ Premium | 2.5l I4 PHEV (304 bhp) | CVT | AWD | TBD / TBD / TBD | $65,230 | |
| RX 450H+ Luxury | 2.5l I4 PHEV (304 bhp) | CVT | AWD | TBD / TBD / TBD | $71,860 | |
| RX 500h F Sport Performance | 2.4l I4 T HEV (366 bhp) | A6 | AWD | 27 / 28 / 27 | 53 | $65,400 |
