| Model/Trim/Package | Engine | MPG | VjI | MSRP | ||
|---|---|---|---|---|---|---|
| RX 350 | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $48,975 |
| RX 350 | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $50,575 |
| RX 350 Premium | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $51,225 |
| RX 350 Premium | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $52,825 |
| RX 350 F Sport Design | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $53,555 |
| RX 350 Premium+ | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $54,715 |
| RX 350 F Sport Design | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $55,155 |
| RX 350 Premium+ | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $56,315 |
| RX 350 F Sport Handling | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $57,825 |
| RX 350 Luxury | 2.4l I4 T (275 bhp) | A8 | FWD | 22 / 29 / 25 | 52 | $59,770 |
| RX 350 Luxury | 2.4l I4 T (275 bhp) | A8 | AWD | 21 / 28 / 24 | 52 | $61,370 |
| RX 350h | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $51,125 |
| RX 350h Premium | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $53,375 |
| RX 350h F Sport Design | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $55,705 |
| RX 350h Premium+ | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $56,865 |
| RX 350h Luxury | 2.5l I4 HEV (246 bhp) | CVT | AWD | 37 / 34 / 36 | 44 | $61,920 |
| RX 450H+ Luxury | 2.5l I4 PHEV (304 bhp) | CVT | AWD | TBD / TBD / TBD | $71,260 | |
| RX 500h F Sport Performance | 2.4l I4 T HEV (366 bhp) | A6 | AWD | 27 / 28 / 27 | 53 | $64,800 |
