The long-running E-Class slots between the entry-level C-Class sedan and the flagship S-Class sedan in the US model range. There are several models with alphanumeric model names to indicate the powertrains within. A 302-bhp 3.5 L V6 powers the E350, whereas a 402-bhp V8 powers the E550. Both are fitted with a 7-speed automatic transmission. Customers can choose to add 4MATIC all-wheel-drive for all-weather traction. A sport appearance package adds body cladding and more aggressive wheels and tires. The ultimate E-Class sedan is the E65 AMG, a factory tuned beast with over 500 horsepower under the hood.

The E-Class sedan features updated powertrains for 2012. The E350 models are powered by a 3.5-liter direct injection V6 rated at 302-bhp, 273 lb-ft of torque. The E550 will include a 4.6-liter V8 rated at 402-bhp, 443 lb-ft of torque. The E63 AMG model is powered by a 518-bhp, 5.5-liter twin turbo V8.