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| E 350 | E 350 4MATIC | E 450 4MATIC | AMG 53 Hybrid | |
| Body | ||||
| Sunroof/Moonroof | Std | |||
| Exterior | ||||
| Side Mirrors - Power | Std | |||
| Lighting | ||||
| Headlamp Type | LED | |||
| Brakes | ||||
| ABS | Std | |||
| Stability Control | Std | |||
| Wheels / Tires | ||||
| Wheel Type | Alloy | |||
| Tire Size F (,R) | 225/55R18 | |||
| Seating | ||||
| Seat Material | Leatherette | |||
| Power Adjustable Seats - 1st Row Driver Side | Std | |||
| Power Adjustable Seats - 1st Row Passenger Side | Std | |||
| Heated Seats - 1st Row | Std | |||
| Ventilated Seats - 1st Row | Opt | |||
| HVAC | ||||
| Air Conditioning | Std | |||
| Automatic Climate Control | Std | |||
| Climate Control Zones | 2 | |||
| Driving Aids | ||||
| Adaptive Cruise Control | Opt | |||
| Cruise Control | Std | |||
| Collision Mitigation Braking | Std | |||
| Blind Spot Detection | Std | |||
| Lane Keeping Assist | Opt | |||
| Infotainment | ||||
| Apple CarPlay | Std | |||
| Navigation System | Opt | Std | Opt | |
| Android Auto | Std | |||
| Convenience | ||||
| Power Windows | Std | |||
| Power Door Locks | Std | |||
| Remote Lock/Unlock | Std | |||