The MDX has been a popular SUV since its introduction in 2001. The MDX provides a luxury car feel with excellent ride, maneuverability, and a cabin that is roomy and comfortable. Under the hood, all versions of the MDX feature a 290 bhp, 3.5L V6 engine. The MDX is available with either front-wheel-drive or Acura's Super-Handling All-Wheel Drive (SH-AWD) system. A nine-speed automatic is the only offered transmission. An available Technology package adds a satellite-linked navigation system and a 501-watt premium surround-sound audio system among other features. The Advance package adds more unusual features such as adaptive cruise control and a collision mitigation braking system. The Entertainment package adds a rear-seat DVD entertainment system and heated rear seats. With Honda's reliability and high resale values, the MDX is an all-around safe bet.

The 2016 MDX has an updated AWD system and a nine-speed automatic transmission.