The long-running E-Class slots between the entry-level C-Class sedan and the flagship S-Class sedan in the US model range. There are several models with alphanumeric model names to indicate the powertrains within. A 302-bhp 3.5 L V6 powers the E350, whereas a 402-bhp V8 powers the E550. Both are fitted with a 7-speed automatic transmission. Customers can choose to add 4MATIC all-wheel-drive for all-weather traction. A sport appearance package adds body cladding and more aggressive wheels and tires. The ultimate E-Class sedan is the E65 AMG, a factory tuned beast with over 500 horsepower under the hood.

The Mercedes-Benz E-Class wears updated styling for 2014. The more aggressively styled front end has 2 larger headlights (as opposed to four), a rounded grille and larger lower air intake. Exterior styling changes also include a new hood, new rear bumper and updated side trim. The interior has an updated instrument cluster and dashboard trim. On the sedan, a new 2.1l turbodiesel model, the E250 BlueTEC replaces the E350 BlueTEC. Power on the top E63 AMG models increases to 550-bhp and those models now include 4MATIC all-wheel-drive for the first time. A new S-Model further increases the performance of the E63 to 577-bhp.