Full-sized cargo vans offer many of the capabilities of a pickup truck with enclosed storage. Passenger van models offer the unmatched capability of hauling lots of passengers while also being able to tow. Unfortunately, full-size vans are some of the largest vehicles on the road. The Express is available in a myriad of configurations ranging from passenger vans and work vans to a bare chassis that serve as the starting point for conversion vans.

A new 6.6l Duramax diesel engine is offered on 3500 series passenger vans. A 4.8l V8 becomes the new standard engine on 2500 series passenger vans.