When it was introduced in 2003, the Murano was a unique combination of a car platform and SUV utility. As the market for FWD-biased SUV designs has matured, the second-generation Murano is now one of many similar offerings in the segment. The Murano has four doors, and two rows of seats for five passengers. The large hatch area can hold up to 31.5 cubic feet of cargo with the rear seats up. A standard 3.5l V6 engine producing 260-bhp is mated to a standard continuously variable transmission (CVT). With an EPA estimated fuel economy rating of 18/24 (city/highway), the Murano lags that of competitive models with turbocharged four-cylinder engines. Murano models carry a high level of standard equipment. Models with leather are available from the mid-thirties.

The 2011 Murano wears a revised front grille and bumper. Murano is now offered in four trim levels: S, SV (new), SL, and LE.