This is the truck for contractors and others who need a versatile and capable cargo hauler. GMC equips the Sierra with range of engines from a 4.3L V-6 to a 6.2L V-8. A choice of 6.5' and 8' bed lengths is available on Regular and Extended Cab models with 2WD or 4WD drivetrains. Braking duties are handled by disc/drum layout. Optional alloy wheels in 17, 18, and 20-inch diameter are available; tire sizes range from P245/45R17 to P275/55R20. The Sierra 1500 is a good value for a full-size truck, and offers a surprisingly refined driving experience.

The Sierra 1500 series trucks see a number of powertrain revisions for 2010. Most 1500 models are powered by either a 4.8L V8 or 5.3L V8. Both engines can run on ethanol and feature variable valve timing and cylinder deactivation. The 6.0L V8 has been dropped. The 6.2L V8 is offered with an extreme towing package. The short box is no longer available with the extended cab.