The MDX has been a popular SUV since its introduction in 2001. The MDX provides a luxury car feel with excellent ride, maneuverability, and a cabin that is roomy and comfortable. Under the hood, all versions of the MDX feature a 300 hp, 3.7L V6 engine. Although many competitors offer V8 engines, the power output of the MDX V6 nearly equals the output of a V8. Acura's Super-Handling All-Wheel Drive (SH-AWD) system is standard. A five-speed automatic is the only offered transmission. An available Technology package adds a satellite-linked navigation system and a 410-watt premium surround-sound audio system among other features. The optional Sport package adds an active damping system, unique interior trim and xenon HID lighting. The Entertainment package adds a rear-seat DVD entertainment system and heated rear seats. With Honda's reliability and high resale values, the MDX is an all-around safe bet.

The MDX wears new front and rear styling for 2010. The interior features revised seats, gauges, buttons and new trim pieces. A thicker steering wheel and paddle shifters are other differences. The 3.7L V6 has been revised with heavier duty components from the block to the connecting rods. A six speed automatic transmission replaces the the five speed automatic. Fuel economy increases by 1 MPG. The Sport package has been replaced with an Advance package that includes 19-inch wheels/tires.