The third generation of the Frontier is longer, wider, and taller than its predecessor. It has a fully boxed frame which is based on the F-alpha chassis from the full-sized Titan. Four wheel disc brakes are standard. Engine choices include a 2.5L I-4 (152 bhp) and 4.0L V-6 (261 bhp). Other notable options include a 6-speed manual or a 5-speed automatic, 2WD or 4WD, and King Cab or Crew Cab. An off-road package adds Bilstein® shocks and a locking rear differential. The Frontier is built in Tennessee.

The 2009 Frontier wears revised front-end styling. A new PRO-4X model joins the lineup.