This is the truck for contractors and others who need a versatile and capable cargo hauler. GMC equips the Sierra with range of engines from a 4.3L V-6 to a 6.0L V-8. While many competitive trucks are available with 5 or 6-speed automatics, the Sierra makes do with two 4-speed units; both are available with a range of axle ratios to suit most needs. Maximum payload for the 1500-Series Sierra is a substantial 1,952 lbs, while towing capacity is up to 8,900 lbs. for 4WD models. A choice of 6.5' and 8' bed lengths is available on Regular Cab models with 2WD or 4WD drivetrains. Braking duties are handled by disc/drum layout. Optional alloy wheels in 17, 18, and 20-inch diameter are available; tire sizes range from P245/45R17 to P275/55R20. The Sierra 1500 is a good value for a full-size truck, and offers a surprisingly refined driving experience.

The Sierra 1500 Crew Cab adds a two-mode hybrid model. Hybrid models feature a 6.0L V8 coupled to GM's two-mode hybrid system. The two-mode hybrid system consists of an electrically variable transmission and nickel-metal hydride battery pack. The Sierra Hybrid is a full hybrid running purely on electric power during certain operating conditions. A new XFE model aims to improve the fuel efficiency. The XFE model features a lowered suspension and soft tonneau cover to improve aerodynamics, while aluminum lower control arms and wheels reduce mass. Low rolling resistance tires are also equipped. As a result, fuel efficiency increases by 1 MPG.