The Ford F-Series is the best-selling pickup in the USA. One of the reasons for its popularity is the wide range of body and powertrain variants for personal use and utility needs. A properly equipped F-150 can tow up to 9900 lbs. and has a 3,060 lbs. payload capacity. A Harley-Davidson® package is available for 2WD and AWD F-150 trucks. Engine choices include a 4.2L V-6, 4.6L V-8, and 5.4L V-8, mated to a 5-speed manual or 4-speed automatic. A Flexible-fuel (E85) 5.4L V-8 option will also be available. Available F-150 packages include: heavy-duty payload package, trailer tow package, snow-plow prep package, and work truck package.

The F-Series receives a new cargo management system for 2008. An optional mid-box storage area is available for fleet vehicles.