The M-Class was the first mainstream SUV from Mercedes-Benz. The second generation of the M-Class is a more road-oriented vehicle that reflects the trend for SUVs to adopt more car-like ride and handling. Competitors in this segment include the BMW X5, Infiniti FX, Cadillac SRX, and Volvo XC90. Mercedes-Benz offers several engine choices, ranging from a 3.5L V-6 to a 6.3 L V-8 (ML63 AMG), as well as a 3.2L V-6 diesel that is unique in its class. A standard 7-speed automatic is optimized for maximum fuel economy. All M-Class models feature standard 4WD, but without locking differentials. An optional off-road package adds a 2.93:1 low-range to the transmission for rock crawling adventures. Sport-oriented customers will prefer the ML63 AMG with its 503-bhp V-8, 20-inch alloy wheels, special AMG exterior trim, Nappa leather interior and bigger brakes. M-Class safety features for hilly terrain include DSR (Downhill Speed Regulation), Hill-Start Assist, and a special Off-Road Mode that changes the calibration of the powertrain and brake systems. Available features include 19-inch alloy wheels (N/A for ML63 AMG), adjustable height air suspension, Bi-Xenon headlights, DVD navigation, rear view camera, adaptive damping system, and walnut interior trim.

The ML550 replaces the ML500. The ML550 features AMG bodywork, 19 inch wheels and running boards. 19 inch wheels become standard on the ML320 CDI and ML350. A 10 year anniversary limited edition ML350 will be offered Fall, 2007