The LaCrosse replaced the long-running Regal as Buick's midsize sedan. With its vertical grille and simulated fender vents, this Buick recalls its predecessors from the 1950s. The LaCrosse is available with two V-6 engines, plus a 5.3L V-8, all coupled to a 4-speed automatic. One unusual feature is the optional 6-passenger seating. Stabilitrak stability control is available, along with a standard sport suspension on the CXS model. Buick aims its midsize sedan at the models as varied as the Chrysler 300, Mercury Milan, and Toyota Camry. In reality, the LaCrosse is more likely to appeal to dedicated Buick customers looking for a quiet, comfortable sedan, at an attractive price.

The LaCrosse gets an updated front end. A new LaCrosse Super joins the lineup. The Super is powered by a 300hp, 5.3L V8.