The Lexus RX was one of the first car-based SUVs to gain popularity. During the boom of SUV sales, the RX offered a strong combination of SUV versatility and entry-level (for Lexus) pricing. Offered in FWD and AWD forms, the RX350 is powered by a 3.5L V6. The Lexus 400H is the hybrid powertrain version. Classified as a full hybrid, the RX400H is capable of running entirely on gasoline or electric power. The complexity of the hybrid powertrain adds improved fuel economy and the bragging rights that come along with that. However, the hybrid version also adds about $10k to the sticker price bringing the MSRP to about $50k with some of the more desirable options.

The 2008 RX features a revised grille design, chromed exterior door handles and new wheel designs. Two new exterior colors: Brandy Wine Mica and Desert Sage Metallic. New interior wood trim Black Bird's-Eye Maple for models with a light grey interior.