The SC430 is a luxurious 2+2 convertible with a retractable top. Distinctive styling makes the SC430 stand out from the more nondescript Lexus models. A 4.3L V-8 mated to a 6-speed automatic is the sole powertrain. Safety features include front-side airbags, ABS, and VSC (Vehicle Stability Control). Other innovative features such as Adaptive Front Lighting System (AFS), voice-activated navigation system, Mark Levinson® audio system are standard.

One of the first convertible hardtops on the market, the SC receives new front-end styling for 2006.