The mid-sized Lexus GS fits in to the Lexus lineup just above the FWD, Camry-based ES and below the flagship LS. Long considered to be the most stylish Lexus, a 2006 model year update pushed the styling cues even farther than before. The GS is offered in four models. The GS350 is powered by a 303hp V6. GS350 is offered in RWD and AWD versions. The RWD GS430 is powered by a 300hp V8. The GS450h is a full gas/electric hybrid model that boosts fuel economy and performance. A restrained interior is finished in wood and leather and offers a competitive list of feature considered mandatory on todays luxury cars.

A 3.5L V6 replaces the 3.0L V6. Output increases to 303 hp and 274 lb-ft of torque. Model names change from GS300 to GS350 accordingly. A 3.5L V6-based gas/electric hybrid is offered in the GS450h.